Biological Sciences

Dr. Teresa Golden

Associate Professor
Departmental Chair

2017 Teresa Golden
Education
:

State University of New York at Albany, BS in Biology

University of Rochester, M.S. & Ph.D. in Molecular Genetics

University of South Alabama, Post-doctoral fellowship

Office: Biological Sciences Building, Room 104

Phone: 580-745-2286

FAX: 580-745-7459

Email: tgolden@se.edu

Advising:
Biotechnology
Biological Health Science Option

Bio:

Dr. Golden received her BS in Biology from the State University of New York at Albany. She continued her education receiving her MS and PhD. in Molecular Biology from the Department of Biology at the University of Rochester in Rochester, New York. Starting in 2000, she worked as a post-doctoral fellow in the Department of Biochemistry and Molecular Biology in the Medical School at the University of South Alabama focusing her research on preventing cancer cell growth. She arrived at Southeastern in 2006 and is currently an Associate Professor and the Chair of the Biological Sciences Department.

Current Research interests:

My ongoing goal is to examine the roles of Phosphatases in the development of human cancer and explore their potential use as drug targets for a treatment of cancer. In the lab now the students and I are specifically studying Protein Phosphatase 5 (PP5). PP5 expression is increased in breast cancer cells. Current work suggests that this increase helps make the cancer cells more resistant to stress resulting from low oxygen conditions (common in tumors). We are studying the signaling pathways involved in surviving this cell stress.

Publications:

  1. Ray, A., Lang, J.D., Golden, T., and Ray, S. (1996). SHORT INTEGUMENT  (SIN1), a gene required for ovule development in Arabidopsis, also   controls flowering time. Development 122: 2631-2638.
  2. Ray, S., Golden, T., and Ray, A., (1996). Maternal effects of the short integument 1 mutation on embryo development in Arabidopsis. Devel. Biology 180: 365-369.
  3. Urban, G., Golden, T., Aragon, I.V., Scammell, J.G., Dean, N.M., and Honkanen, R.E., (2001). Identification of an Estrogen-inducible Phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an Estrogen-independent phenotype when expressed constitutively. JBC  276: 27638–27646.
  4. Golden, T., Dean, N.M., and Honkanen, R.E. (2002). Use of antisense oligonucleotides: Advantages, controls, and cardiovascular tissue. Microcirculation 9: 51-64.
  5. Honkanen, R.E. and Golden T. (2002). Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? Current Medicinal Chemistry 9(22): 2055-2075.
  6. Golden, T.A., Schauer, S.E., Lang, J.D., Pien, S., Mushegian, A.R., Grossniklaus, U., Meinke, D.W., and Ray, A. (2002). SHORT INTEGUMENTS1 / SUSPENSOR1 / CARPEL FACTORY, a Dicer homologue, is a maternal-effect gene required for embryo development in Arabidopsis. Plant Physiology 130(2): 808-822.
  7. Urban, G., Golden, T., Aragon, I.V., Cowsert, L., Cooper S.R., Dean, N.M., and Honkanen, R.E., (2003). Identification of a functional link for the p53 tumor suppressor protein in Dexamethasone-induced growth suppression. JBC 278: 9747–9753.
  8. Golden, T.A, Honkanen, R.E. (2003). Regulating the expression of Protein Phosphatase type 5. Methods Enzymol. 366: 372-90.
  9.  Zhou, G., Golden, T., Aragon, I.V., and Honkanen, R.E., (2004). Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade. JBC 279: 46595-46605.
  10.  Golden, T., Aragon, I.V., Zhou, G., Cooper, S.R., Dean, N.M., and Honkanen, R.E., (2004). Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice. Cancer Lett. 215:95-100.

Patent:

Animesh Ray and Teresa Golden, “Gene encoding SHORT INTEGUMENTS1 and uses thereof” Issued May 18, 2004, US 6,737,561 B1.

Office Hours:

Mon. 11-12, 3-5 Tues. 9-11:30, 4-5, Thurs. 9-11, Fri. 11-12:30